An Open-Label, Phase 1/2 Study of JCAR017 in Subjects with Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (017004)

Cancer Categories

Hematologic (Blood Cancers)

Karmanos Trial ID

2019-024

NCT ID

NCT03331198

Age Group

Adult

Scope

National

Phase

Phase I/II

Principal Investigator

Abhinav
Deol, M.D.
Oncology - Hematology, Oncology - Medical View Profile

Objective:

Phase 1 Monotherapy (open-label, single-arm, dose-finding for JCAR017 monotherapy):

Primary Objective(s):

To evaluate the safety and to determine the RD of JCAR017 in subjects with R/R CLL or SLL

Phase 1 Combination (open-label, single-arm, dose-finding for ibrutinib + JCAR017 combination in subjects continuing with ibrutinib treatment):

Primary Objective(s):

To evaluate the safety of ibrutinib + JCAR017 and to determine the RD of JCAR017 in combination with ibrutinib in subjects with R/R CLL or SLL

Phase 2 Expansion (open-label, single-arm, expansion of JCAR017 monotherapy at RD):

Primary Objective(s):

To evaluate antitumor activity of JCAR017 monotherapy at the RD in subjects with R/R CLL or SLL as determined by complete remission (CR) rate (including complete remission with incomplete marrow recovery [CRi]) based on independent review using International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2018 guidelines

Secondary Objective(s):

To evaluate the safety and tolerability of JCAR017 monotherapy at the RD in subjects with R/R CLL or SLL
To assess the depth and durability of antitumor activity of JCAR017 monotherapy at the RD in subjects with R/R CLL or SLL
To estimate the effect of JCAR017 monotherapy at the RD on disease progression and survival
To assess health-related quality of life (HRQoL) in subjects with R/R CLL or SLL treated with JCAR017 monotherapy at the RD
To assess health economics and outcomes research (HEOR) in subjects with R/R CLL or SLL treated with JCAR017 monotherapy at the RD

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Eligibility

Inclusion Criteria:

Diagnosis of:

CLL with an indication for treatment based on the Investigator's opinion and measurable disease, or
SLL (lymphadenopathy and/or splenomegaly and < 5×10^9 CD19+ CD5+ clonal B lymphocytes/L [< 5000/µL] in the peripheral blood at diagnosis with measurable disease that is biopsy-proven SLL)

Subjects (other than those in the ibrutinib + JCAR017 combination therapy and DEME cohort) must have received and failed Bruton tyrosine kinase inhibitor (BTKi) treatment or have been deemed ineligible for BTKi therapy.
Subjects in the JCAR017 monotherapy cohorts must have received previous treatment as follows:

Monotherapy cohorts EXCEPT DEME cohort: Subjects with CLL or SLL and high-risk features must have failed at least 2 lines of prior therapy.
Monotherapy cohorts EXCEPT DEME cohort: Subjects with CLL or SLL and standard-risk features must have failed at least 3 lines of prior therapy.
DEME cohort ONLY: Subjects with relapsed or refractory CLL or SLL, irrespective of cytogenetic risk features, must have received at least 2 lines of prior therapy including a BTKi and a BCL2i.

Subjects in the ibrutinib + JCAR017 combination therapy cohort must either:

be receiving ibrutinib and progressing at the time of study enrollment
be receiving ibrutinib for at least 6 months with a response less than complete response/remission (CR) and have high-risk features as defined in inclusion criterion 5a
have BTK or PLCgamma2 mutations per local laboratory assessment, with or without progression on ibrutinib
have previously received ibrutinib and have no contraindications to restarting ibrutinib

Eastern Cooperative Oncology Group performance status of ≤ 1
Assessed by the Investigator to have adequate bone marrow function to receive lymphodepleting chemotherapy
Adequate organ function, defined as:

Serum creatinine ≤ 1.5 × age-adjusted upper limit of normal (ULN) OR calculated creatinine clearance > 30 mL/min
Alanine aminotransferase ≤ 5 × ULN and total bilirubin < 2.0 mg/dL (or < 3.0 mg/dL for subjects with Gilbert's syndrome or leukemic infiltration of the liver)
Adequate pulmonary function, defined as ≤ Common Terminology Criteria for Adverse Events (CTCAE) Grade 1 dyspnea and saturated oxygen (SaO2) ≥ 92% on room air
Adequate cardiac function, defined as left ventricular ejection fraction ≥ 40% as assessed by echocardiogram or multiple uptake gated acquisition scan performed within 30 days prior to determination of eligibility

Subject either currently has central vascular access or is a candidate to receive central vascular access or peripheral vascular access for leukapheresis procedure.
If prior CD19-targeted therapy has been administered, subject must have CD19-positive disease confirmed by immunohistochemistry or flow cytometry since completing the prior CD19-targeted therapy.
Subjects in ibrutinib + JCAR017 combination cohort must have progressed on a BTKi and have received prior therapy with venetoclax
Subjects in venetoclax + JCAR017 combination cohort must:

have failed at least 1 prior line of therapy, including failed BTKi therapy or have been deemed ineligible to receive BTKi
be venetoclax naive (required for dose expansion) or
if prior venetoclax (only for dose escalation)
have no contraindictions to re-initiation of venetoclax based on prior intolerance and have had at least 6 months elapsed since the last dose of venetoclax, if either, best response was stable disease, or subject experienced disease progression on venetoclax, or within 6 months of venetoclax discontinuation

subjects in the venetoclax + JCAR017 combination must have hemoglobin >=9 g/dL, absolute neutrophil count >=500mm3 and platelets>= 75,000/mm3, unless cytopenias are judged by investigator to be due to CLL infiltration of the bone marrow
must have diagnosis of CLL or SLL with an indication for treatment based on the investigator's opinion and measurable disease (any of the following measurable lymph nodes ≥1.5 cm in the greatest transverse diameter and/or hepatomegaly or splenomegaly) and demonstration of CLL cells in the peripheral blood by flow cytometry

Exclusion Criteria:

Subjects with known active central nervous system (CNS) involvement by malignancy. Those with prior CNS disease that has been effectively treated will be eligible if treatment was completed at least 3 months prior to enrollment with no evidence of symptomatic disease and stable abnormalities on repeat imaging.
History of another primary malignancy that has not been in remission for at least 2 years. (The following are exempt from the 2-year limit: nonmelanoma skin cancer, completely resected stage 1 solid tumor with low risk for recurrence, curatively treated localized prostate cancer, cervical carcinoma in situ on biopsy or a squamous intraepithelial lesion on Pap smear, and in situ breast cancer that has been completely resected.)
Subjects with Richter's transformation
Prior treatment with any gene therapy product
Active hepatitis B, active hepatitis C, or active human immunodeficiency virus (HIV) infection
Systemic fungal, bacterial, viral, or other infection that is not controlled
Presence of acute or extensive chronic graft versus host disease (GVHD)
History of any one of the following cardiovascular conditions within the past 6 months: Class III or IV heart failure as defined by the New York Heart Association (NYHA), cardiac angioplasty or stenting, myocardial infarction, unstable angina, or other clinically significant cardiac disease
History or presence of clinically relevant CNS pathology such as epilepsy, generalized seizure disorder, aphasia, stroke with current neurologic sequelae, severe brain injuries, dementia, Parkinson's disease, cerebellar disease,cerebral edema, or psychosis
Pregnant or nursing (lactating) women
Use of any of the following medications or treatments within the noted time prior to leukapheresis:

Alemtuzumab within 6 months prior to leukapheresis
Allogeneic hematopoietic stem cell transplant within 100 days prior to leukapheresis
Cladribine within 3 months prior to leukapheresis
Donor lymphocyte infusions (DLI) within 2 months prior to leukapheresis
Radiation including large bone marrow fields such as sternum or pelvis within 6 weeks prior to leukapheresis
Fludarabine within 4 weeks prior to leukapheresis
GVHD therapies such as calcineurin inhibitors, methotrexate or other chemotherapeutics, mycophenolate mofetil, rapamycin, or immunosuppressive antibodies (such as anti-tumor necrosis factor-α [TNFα], anti-interleukin-6 [IL-6], or anti-interleukin-6 receptor [IL 6R]) within 4 weeks prior to leukapheresis
Cyclophosphamide, ifosfamide, bendamustine, chlorambucil, or melphalan within 2 weeks prior to leukapheresis
Therapeutic doses of corticosteroids (defined as > 20 mg/day prednisone or equivalent) within 7 days prior to leukapheresis
Anti-CD20 monoclonal antibodies within 7 days prior to leukapheresis
Venetoclax within 4 days prior to leukapheresis
Idelalisib or duvelisib within 2 days prior to leukapheresis
Lenalidomide or covalent and non-covalent BTKi within 1 day prior to leukapheresis
Experimental agents, including off-label use of approved drugs (with the exception of acalabrutinib which may be continued up to the day before leukapheresis), within 4 weeks prior to leukapheresis unless progression is documented on the experimental therapy and at least 3 half-lives have elapsed prior to leukapheresis

Uncontrolled medical, psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol, as judged by the Investigator; or subject unwillingness or inability to follow the procedures required in the protocol
Progressive vascular tumor invasion, thrombosis, or embolism
Deep vein thrombosis or embolism not managed on a stable regimen of anticoagulation
Use of any of the following medications or treatments within the noted time prior to leukapheresis lenalidomide or acalabrutinib within 1 day prior to leukapheresis experimental agents, including off-label use of approved drugs, within 4 weeks prior to leukapheresis.
Venous thrombosis or embolism requiring treatment but not managed on a stable regimen of anticoagulation

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Detroit, MI 48201
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Applicable Disease Site

Therapies, Drugs, Devices