Having a large clinical trial portfolio means giving patients treatment options often not available anywhere else, and years before they become the standard of care. To learn more about Karmanos Cancer Institute clinical trials or to see if a trial is right for you, please call 1-800-KARMANOS (1-800-527-6266) or request an appointment below
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  • A Phase 1b Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of ATP150/ATP152, VSV-GP154 and Ezabenlimab (BI 754091) in Patients With KRAS G12D/G12V Mutated Pancreatic Ductal Adenocarcinoma (KISIMA-02)

    Cancer Categories
    • Gastrointestinal (GI)
    Karmanos Trial ID
    • 2023-022
    NCT ID
    • NCT05846516
    Age Group
    • Adult
    Scope
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase I
    Includes initial studies to determine the metabolism and pharmacologic actions of drugs in humans, the side effects associated with increasing doses, and to gain early evidence of effectiveness; may include healthy participants and/or patients.
    • Phase I
    Principal Investigator

    Objective:

    Primary Objectives:

    Part A and Part B

    • To assess the safety and tolerability of the study treatment.

    Part C

    • To assess efficacy in regards of disease-free survival of the study treatment.

    Secondary Objectives:

    Part C

    • To assess ctDNA clearance in ctDNA positive patients.
    • To assess ctDNA non-progression in ctDNA negative patients.
    • To assess the safety and tolerability of the study treatment.
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    NCI Dictionary of Cancer Terms
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    • Locations

    Locations

    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Phone: 800-527-6266

    Karmanos Cancer Institute at Weisberg Cancer Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
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    Phone: 800-527-6266