Cyclotron & Radiochemistry Core

Mission of the Core

The Cyclotron & Radiochemistry (C&R) Core is an FDA-regulated facility responsible for the research & development of novel PET radiotracers to advance early diagnosis and treatment of diseases.

The Cyclotron & Radiochemistry (C&R) Core is supported, in part, by NIH Center grant P30 CA022453 to the Karmanos Cancer Institute at Wayne State University.

Core Services Available

  • (A)NDA PET radiotracer routine manufacturing.
  • Research PET radiotracer development, including novel radiotracers for preclinical animal imaging, Radioactive Drug Research Committee (RDRC) and Investigational New Drug (IND) study.
  • PET radiotracers productions to meet preclinical and clinical needs.

Resources (Clinical)

  • GE PETtrace 800 cyclotron for PET radioisotopes production, such as F-18, C-11, N-13 and O-15.
  • cGMP compatible clean room for PET drug production and dose preparation.
  • Four Comecer mini hot cells for PET drug synthesis and two vertical ISO 5 hot cells with manipulators and dose calibrators for dose preparation.
  • Two GE Fastlab modules for FDG production.
  • Capintec CRC-25 PET radioisotope dose calibrator.
  • Rotem radiation monitoring system with multiple detectors.
  • Comecer fume hood for QC test.
  • Canberra multi-channel analyzer.
  • EZ Radio-TLC scanner.
  • Agilent 7890A gas chromatography.
  • Hydrogen generator.
  • Endosafe PTS pyrogen testing module.
  • Thermo Heratherm incubation oven for sterility test.
  • Ludlum model 375 hand and foot radiation monitor.
  • Ludlum model 14C radiation monitor with pancake detector
  • Millipore deionized water unit.
  • Mettler Analytical Balance AE260.
  • Labrepco Futura refrigerator.
  • Epson WF-6090 printer.

Resources (Research)

  • Four Von Galen vertical hot cells for radiation shielding.
  • F-18/C-11 modules for research PET radiotracers production.
  • Waters UPLC system with UV and NaI Rad detector.
  • Bioscan AR-2000 Radio-TLC scanner with control computer and software.
  • Endosafe PTS pyrogen testing module.
  • Laminar flow hood for quality control test.
  • Isotemp incubator for sterility test.
  • VMware radiation monitoring system with multiple detectors.
  • Three Capintec 712M control modules with ionization chambers.
  • Capintec CAPRAC-R radiation counter.
  • Ludlum model 14C radiation monitor with pancake detector
  • Ludlum model 177 ratemeter with detector
  • Millipore deionized water unit.
  • Mettler AT261 analytical balance.
  • Lexmark X656DTE printer.

Current Radiotracers in C&R Core

Over 20 PET radiotracers have been developed and/or investigated in the C&R Core. Currently, the Core is focused on RDRC/IND research projects using [18F]FDG, [18F]FLT and its analogs, [11C]AMT, [11C]PK11195, [11C]acetate, [18F]FMPEP-d2 and [18F]FETrp. Meanwhile, work is also in progress on novel radiotracers, such as [18F]TFAHA and [18F]Diabody, for animal microPET imaging. Table 1, below, lists the current radiotracers in production in the C&R Core.

Table 1. List of PET radiotracers in the C&R Core.

PET drugs

Target

Application

[15O]H2O

Blood flow, oxygen

Brain activation, heart

[15O]O2

Brain oxygen utilization

Stroke, fMRI validation

[15O]CO

Oxidative metabolism

Brown fat

[13N]ammonia

Myocardial perfusion

Coronary artery disease

[18F]FDG (2-[18F]fluoro-2-deoxy-glucose)

Glucose metabolism

Epilepsy, heart, tumor

[18F]FLT, [18F]FAU, [18F]FMAU, [18F]FBAU, [18F]FIAU, [18F]FAG

DNA synthesis, thymidine analog

Tumor, epilepsy

[18F]FMPEP-d2

Cannabinoid CB1 receptors

Depression, schizophrenia, and obesity

[18F]TFAHA

Histone deacetylases IIa

Brain

[18F]Diabody

Interferon-γ

Tumor

[18F]FETrp (1-(2-18F-fluoroethyl)-L-tryptophan)

F-18 version AMT

F-18 version AMT

[11C]AMT (a-11C-methyl-L-tryptophan)

Serotonin synthesis, kynurenine pathway metabolism

Autism, epilepsy, migraine, Tourette syndrome, tumor

[11C]PK11195

Peripheral benzodiazepine receptors

Inflammation

[11C]acetate

Oxidative metabolism

Cardiomyopathy

[11C]HED, [11C]FMZ, [11C]DWAY

[11C]methionine, [11C]leucine,[11C]Doxepine

Sympathetic innervation, GABAA, protein synthesis 5HT1A, Histamine H1 receptors

Epilepsy, seizures, autism, brain development

Contact

Huailei (Ray) Jiang, Ph.D.
Director
Cyclotron & Radiochemistry Core
jiangh@karmanos.org